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Efficacy of Hyperlipidemia Treatment (ACE inhibitors, drug side effects) |
PHGN |
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Signs/symptoms: |
Efficacy of statins and gemfibrozil in hyperlipidemia, efficacy of betablocker in heart failure, efficacy of ACE inhibitors. |
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Complications: |
Hyperlipidemia, hypertension. |
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Early diagnosis/treatment: |
Yes |
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Material required: |
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Blood tubes: |
EDTA whole blood (do not freeze, do not centrifugate) |
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Mouth brush: |
No |
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Chromosomal localization: |
17q23 |
OMIM number: |
106180 |
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Angiotensin I converting enzyme |
ACE |
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Gene regions tested: |
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Gene regions: |
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Amino acid positions: |
insertion/deletion polymorphism |
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Nucleotide positions: |
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Test methods: |
Sequencing |
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TP REVAL: |
250 |
TP Value: |
0.9 |
CHF |
225.00 |
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Other europe: |
EUR |
160.00 |
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Other regions: |
USD |
call |
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| Maitland-van der Zee AH, Stricker BH, Klungel OH, Kastelein JJ, Hofman A, Witteman JC, Leufkens HG, Duijn CM, Boer Ad A. Effectiveness of HMG-CoA reductase inhibitors is modified by the ACE insertion deletion polymorphism. Atherosclerosis. 2004;175:377-379. | |
| McNamara DM, Holubkov R, Janosko K, Palmer A, Wang JJ, MacGowan GA, Murali S, Rosenblum WD, London B, Feldman AM. Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure. Circulation. 2001;103:1644-1648. | |
| Bosse Y, Vohl MC, Dumont M, Brochu M, Bergeron J, Despres JP, Prud'homme D. Influence of the angiotensin-converting enzyme gene insertion/deletion polymorphism on lipoprotein/lipid response to gemfibrozil. Clin Genet. 2002;62:45-52. | |
