Alzheimer Dementia, sporadic, association marker ACE

Geriatry

13.003

Alzheimer Dementia, sporadic, association marker ACE

AD2

Signs/symptoms:	Dementia, late onset, sporadic
Complications:	Neuritic plaques and neurons with neurofibrillary tangles.
Early diagnosis/treatment:	Yes

Association between homozygosity for both the ACE I and D allele polymorphisms and Alzheimer's disease (AD).

Material required:
Blood tubes:	EDTA whole blood (do not freeze, do not centrifugate)
Mouth brush:	Yes

Chromosomal localization:

17q23

OMIM number:

106180

Angiotensin I converting enzyme (association marker)

ACE

Gene regions tested:
Gene regions:
Amino acid positions:	insertion/deletion polymorphism
Nucleotide positions:
Test methods:	Sequencing

Prices:

Switzerland:

8820.00

8811.01

8819.01

	TP REVAL:	250	TP Value:	0.9	CHF	225.00
Other europe:	EUR					160.00
Other regions:	USD					call

References:

De Bruin, T. W. A.; Mailly, F.; Van Barlingen, H. H. J. J.; Fisher, R.; Castro Cabezas, M.; Talmud, P.; Dallinga-Thie, G. M.; Humphries, S. E. Lipoprotein lipase gene mutations D9N and N291S in four pedigrees with familial combined hyperlipidaemia. Europ. J. Clin. Invest. 26: 631-639, 1996.

Narain, Y.; Yip, A.; Murphy, T.; Brayne, C.; Easton, D.; Evans, J. G.; Xuereb, J.; Cairns, N.; Esiri, M. M.; Furlong, R. A.; Rubinsztein, D. C. The ACE gene and Alzheimer's disease susceptibility. J. Med. Genet. 37: 695-697, 2000.

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Alzheimer Dementia, sporadic, association marker ACE