Li-Fraumeni Syndrome (sequence of exons 5,6,7)

Oncology

09.001

Li-Fraumeni Syndrome (sequence of exons 5,6,7)

LFS1

Signs/symptoms:	Cancer
Complications:	Soft tissue sarcomas and osteosarcomas, breast cancer, brain tumors, leukemia, and adrenocortical carcinoma
Early diagnosis/treatment:	Yes

Li-Fraumeni syndrome (LFS) is a clinically and genetically heterogeneous inherited cancer syndrome. LFS is characterized by autosomal dominant inheritance and early onset of tumors, multiple tumors within an individual, and multiple affected family members.

Material required:
Blood tubes:	EDTA whole blood (do not freeze, do not centrifugate)
Mouth brush:	No

Chromosomal localization:

17p13.1, 9p21

OMIM number:

191170

Tumor protein p53

TP53

Gene regions tested:
Gene regions:	exons 5, 6, 7, 8
Amino acid positions:
Nucleotide positions:
Test methods:	Sequencing

Prices:

Switzerland:

8820.00

8811.01

8819.01

8810.19

	TP REVAL:	1600	TP Value:	0.9	CHF	1440.00
Other europe:	EUR					950.00
Other regions:	USD					call

References:

Varley JM, Evans DGR, Birch JM. Li-Fraumeni syndrome: a molecular and clinical review. Brit. J. Cancer 76:1-14,1997.

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Li-Fraumeni Syndrome (sequence of exons 5,6,7)